Synergistic Effect of Cypermethrin and Sodium Fluoride on Kidney Histo Pathology of Albino Mice

Abstract

The aim of the resent study is to understand the renal toxicity, induced by cypermethrin and sodium fluoride (NaF) separately and combined in albino mice. Albino mice were treated with cypermethrin and sodium fluoride (NaF), separately and in combination, with 1/10th of the LD₅₀ dosage of cypermethrin and NaF for individual administration by oral gavage (i.e., 8.5 mg/kg bw and 5.6 mg/kg bw, respectively) and 1/20th of the LD₅₀dose of cypermethrin and NaF for combined administration (i.e., 4.25 mg/kg bw and 2.8 mg/kg bw, respectively). Separate or combined treatment resulted in histopathological changes in the kidney tissue such as degenerative changes in bowman’s capsule (DGBC), distal convoluted tubules (DGDCT),necrotic changes in glomerulus (NCG), atrophied glomerulus (ATG), necrotic change in distal convoluted tubules (NCDCT), necrotic change in bowman’s capsule (NCBC) and necrosis in proximal convoluted tubules (NCPCT), severe necrotic changes in proximal convoluted tubules (SNCPCT) and distal convoluted tubules ( SNCDCT) were observed. The changes were more in combination than individual treatment, this may be because of a synergistic effect of cypermethrin and NaF.