The Results of Biochemical and Pathomorphological Studies of The Internal Organs of White Rats on The Model of Experimental Glomerulonephritis

Abstract

Objective: to study the effect of bread with the addition of 5 and 10% soy flour on the body of rats and to assess biochemical and pathological changes in animal organs in experimental glomerulonephritis. Material and methods: The glomerulonephritis model was reproduced by injecting 5 ml of isolated adopted lymphocytes intravenously through the tail vein to intact white mongrel rats. Results: the introduction of bread enriched with 5% and 10% soy flour into the diet of animals with experimental glomerulonephritis is safe, does not cause additional pathologies and death of animals and slightly improves the course of the disease. The improvement of the condition is confirmed by the results of biochemical studies of blood serum and histomorphological studies of the internal organs of white rats with experimental glomerulonephritis. Conclusions: the effectiveness of a low-protein diet based on the appointment of bakery products from wheat-soy flour in experimental glomerulonephritis is substantiated.