DESIGN NOVEL SYNTHETIC ROOT OF BENZOXAZOLE DERIVATIVES AS IN VITRO ACTIVITIES: A RESEARCH ARTICLE

Abstract

Being a hetero- cyclic moiety, benzoxazole finds application in much medicinal research as an initial reactant. Benzoxazole derivatives have unique significance in the field of medical research due to their incredible biological potential. During recent year Benzoxazole derivative showed interesting development in medicinal research. Many Novel benzoxazole derivatives (G₃-G₆) were formed by using 4- methyl 2-amiono phenol reagent with methanol, potassium hydroxide, carbon di- sulfide. We observed the process employing thin-layer chromatography and interpreted spectral analysis via NMR, LC-MS, IR Spectrometry and antibacterial activity done by MIC method with Escherichia Coli a gram negative bacteria, Staphylococcus aureus a gram positive bacteria and anti-tubercular activities done through alamar blue dye technique(ABD) using Mycobacterium Tuberculosis(MT) bacteria . Some tested derivatives showed potent activity