Unveiling the Anxiolytic Potential of Epimedium Extract in Sleep-Deprived Mice
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Abstract
Aim: To investigate the anxiolytic potential of Epimedium extract in sleep-deprived mice compared to diazepam.
Objective: To evaluate the anxiolytic effects of Epimedium extract in sleep-deprived mice, using behavioral and biochemical assays, and compared the effects with those of diazepam.
Background: Anxiety disorders and sleep deprivation commonly coexist, worsening each other's symptoms and impacting overall well-being. Epimedium L, a traditional herbal remedy, is known for its adaptogenic properties, which may offer relief from stress-related conditions.
Method: Male Swiss albino mice were divided into five groups: control, sleep-deprived, two treatment groups of Epimedium and one standard group of diazepam. The effects of treatment were assessed using various behavioral tests, such as actophotometer, elevated zero maze, and light/dark test. Followed by biochemical assays measuring levels of oxidative stress markers, neurotransmitters, and enzymes associated with anxiety
Result: The study found that Epimedium extract significantly reduced anxiety-like behavior in sleep-deprived mice, with effects comparable to diazepam in a dose dependent manner. The extract also influenced oxidative stress markers and neurotransmitter levels, suggesting a multifaceted mechanism of action.
Conclusion: Epimedium extract has demonstrated significant potential as an effective anxiolytic agent, offering a safer alternative to diazepam due to its reduced side effect profile. This positions it as a promising option for managing anxiety disorders.
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