Recent Advances In Transethosomal Drug Delivery System To Enhance The Accuracy And Efficacy In Medical System
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Abstract
Transethosome is one of very recent advancement in the ever-changing field of drug delivery system. It is a vesicular carrier system which transdermally delivers the drug and is thus an alternative for oral drug delivery system. TDDS consists of adhesive devices (or vesicles) which contain a predetermined amount of drug in enclosed area. It uses skin an entry port which permeates the drug to directly enter the blood stream. As skin has stratum corneum (SC) – a layer of dead cells – it is considered as rate limiting barrier for permeation of drug transdermally. Transethosomes help in overcoming this problem as they are ethanol based lipophilic carriers which then fluidizes the SC layer which then allows the drug penetration through the skin. Along with this transethosome also contain edge activator which helps in enhanced skin permeation. This article reviews the various properties, methods of preparation and advantages and disadvantages that transethosome have over other drug delivery system.
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References
Abdulbaqi IM, Darwis Y, Khan NA, Assi RA, Khan AA. Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. International Journal of Nanomedicine. 2016;11:2279-2304. doi: 10.2147/IJN.S105016.
Albash R, Abdelbary AA, Refai H, El-Nabarawi MA. Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation. Int J Nanomedicine. 2019;14:1953‐1968. Published 2019 Mar 15. doi:10.2147/IJN.S196771
Ansari, M.D., Ahmed S., Imam S.S., Khan I., Singhal S., Sharma M., and Sultana Y.(2019). CCD based development and characterization of nano-transethosome to augment the antidepressant effect of agomelatine on Swiss albino mice. Journal of Drug Delivery Science and Technology, 54, 101234,
Biju S. S., Talegaonkar S., Mishara P. R., Khar R. K., Vesicular systems: An overview. Indian J. Pharm. Sci., 210, 141—151 (2010). doi: 10.4103/0250-474X.25707
Del Rosso JQ, Levin J. The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. J Clin Aesthet Dermatol. 2011 Sep;4(9):22-42. PMID: 21938268; PMCID: PMC3175800.
Garg, V., Singh, H., Bhatia, A. et al. Systematic Development of Transethosomal Gel System of Piroxicam: Formulation Optimization, In Vitro Evaluation, and Ex Vivo Assessment. AAPS PharmSciTech 18, 58–71 (2017). doi: 10.1208/s12249-016-0489-z
Gawkrodger DJ. Dermatology, An Illustrated Colour Text. 3rd ed. Edinburgh: Churchill Livingstone; 2002.
Jain, S., Jain, V., & Mahajan, S. C. (2014). Lipid Based Vesicular Drug Delivery Systems. Advances in Pharmaceutics, 2014, 1–12. doi:10.1155/2014/574673
Kumar L, Verma S, Singh K, Prasad DN, Jain AK. 2016. Ethanol Based Vesicular Carriers in Transdermal Drug Delivery: Nanoethosomes and Transethosomes in Focus. NanoWorld J 2(3): 41-51.
Koushlesh Kumar Mishra, Chanchal Deep Kaur, Shekhar Verma, Anil Kumar Sahu, Deepak Kumar Dash, Pankaj Kashyap and Saraswati Prasad Mishra (February 13th 2019). Transethosomes and Nanoethosomes: Recent Approach on Transdermal Drug Delivery System, Nanomedicines, Muhammad Akhyar Farrukh, IntechOpen, doi : 10.5772/intechopen.81152.
Lalit Kumar and Puneet Utreja*, Formulation and Characterization of Transethosomes for Enhanced Transdermal Delivery of Propranolol Hydrochloride, Micro and Nanosystems (2020) 12: 38. doi: 10.2174/1876402911666190603093550
Oh, Y.-K., Kim, M. Y., Shin, J.-Y., Kim, T. W., Yun, M.-O., Yang, S. J., … Choi, H.-G. (2006). Skin permeation of retinol in Tween 20-based deformable liposomes: in-vitro evaluation in human skin and keratinocyte models. Journal of Pharmacy and Pharmacology, 58(2), 161–166. doi:10.1211/jpp.58.2.0002
Rastogi, V., Yadav,P., 2012. Transdermal drug delivery system: An overview, Asian Journal Of Pharmaceutics 6(3),161-170
Ruba B., Laura C., Khan I., Roberts M., Ehtezazi T. The effect of ethanol evaporation on the properties of inkjet produced liposomes, DARU Journal of Pharmaceutical Sciences, 10.1007/s40199-020-00340-1, (2020).
Shaji J and Bajaj R: Transethosomes: a new prospect for enhanced transdermal delivery. Int J Pharm Sci Res 2018; 9(7): 2681-85. doi: 10.13040/IJPSR.0975-8232.9(7).2681-85.
Shaji, J. and Garude, S. 1. Transethosomes and ethosomes for enhanced transdermal delivery of ketorolac tromethamine: a comparative assessment. International Journal of Current Pharmaceutical Research. 6, 4 (1), 88-93.
Song CK, Balakrishnan P, Shim CK, Chung SJ, Chong S, Kim DD. A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro/in vivo evaluation. Colloids Surf B Biointerfaces. 2012;92:299‐304. doi:10.1016/j.colsurfb.2011.12.004
Moolakkadath T.,, Abdul Ahad MA., Imam SS., Iqbal B., Sultana Y., Mujeeb M, & Iqbal Z. (2018) Development of transethosomes formulation for dermal fisetin delivery: Box–Behnken design, optimization, invitro skin penetration, vesicles–skin interaction and dermatokinetic studies, Artificial Cells, Nanomedicine, and Biotechnology, 46:sup2, 755-765, doi: 10.1080/21691401.2018.1469025
Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release. 2000;65(3):403‐418. doi:10.1016/s0168-3659(99)00222-9