Advocating Platelet Rich Plasma Therapy (PRP) as Assuring Treatment Modality in Acute Fissure in Ano-A Case Report

Abstract

PRP or autologous platelet-rich plasma, has been hailed as a successful method of treating wounds. There is, however, still a shortage of data to back up its application in patients with both acute and chronic wounds. This study set out to thoroughly investigate the efficacy, synergy, and potential mechanism of PRP-mediated treatment for acute fissure-in-ano. Acute fissure with indications of pain, bleeding, and elevated sphincter tone was identified at six o'clock. As a control, PRP was applied to the area of the fissure. The pace of fissure healing, as well as the reduction in discomfort, bleeding, and sphincter tone, were evaluated on the third and tenth days. PRP significantly enhanced fissure healing, which was connected to wound healing control, angiogenesis augmentation, re-epithelialization, and collagen deposition. As PRP raises local vascular intensity, enhances re-epithelialization, and is linked to increased growth factor production, it dramatically improves the healing process of fissures while also reducing discomfort, bleeding, and worsened sphincter tone.